Goals before the break from Spinazzola and Amir Rrahmani earned a win for the visitors at Lazio in a fixture marred by a trio of red cards.
Three points propels Napoli to just one point behind of Italian league leaders AC Milan, who prevailed on Friday. Inter hold third place but have a chance to go back to the summit with a victory in their later fixture.
Despite missing several key players, Napoli commanded the game with patient attacks. The opener came when Matteo Politano's delivery was drilled home by Spinazzola at the back post.
The lead was doubled in the 32nd minute as Rrahmani powered a header from another Politano free-kick into the bottom corner. They came close to a third shortly after when Eljif Elmas watched his effort rattle against the woodwork.
After the break brought further worry for the away side when a player was forced off. This incident triggered a short altercation, resulting in bookings for a Napoli defender and Lazio's Noslin—who then was shown a second caution for a foul.
"My compliments to the lads, playing with this level of technical ability and physical strength without letting Lazio have control is not easy," remarked the winning manager. "Our performance was at a exceptional level of play."
Tensions boiled over again near the end as two opponents were embroiled in a fierce exchange, prompting the coach to intervene. The two players were shown red cards for their involvement in the incident.
Over in La Liga, the Andalusian side endured a heavy loss at home to struggling Levante. Levante took control with a fine team goal before adding two further strikes in the second half to complete a convincing victory.
In other news, Los Blancos host major must-win when they play Real Betis, after their arch-rivals increased their advantage at the summit. Later on late match, Atlético Madrid travel to face Real Sociedad.
Turning to Ligue 1, a landmark capital derby is scheduled as Paris FC face powerhouses PSG. The fixture represents the inaugural top-flight encounter between the neighbors in over 36 years, adding significant intrigue to the weekend's action.
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